Animation depicting the role of barrier function in disease pathology and Alba’s therapeutic approach through tight junction regulation and inhibition of increased paracellular permeability. Requires Flash Player 8 or greater.

Part A
Tight Junction Physiology
Part B
Alba's Therapeutic Approach to Celiac Disease
Part A & B

Barrier dysfunction has been implicated as a causal factor in many autoimmune and inflammatory diseases.  Alba’s discovery efforts are focused on the regulation of tight junctions, as depicted in the videos above.

By inhibition of inappropriate permeability through regulation of tight junctions, Alba strives to modify disease progression while downregulating the associated inflammatory cascade.