Animation depicting the role of barrier function in disease pathology and Alba’s therapeutic approach through inhibition of increased paracellular permeability. Requires Flash Player 8 or greater.
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Part A
Tight Junction Physiology |
Part B
Alba's Therapeutic Approach to Celiac Disease |
Combined
Part A & B |
Barrier dysfunction has been implicated as a causal factor in many autoimmune and inflammatory diseases. Alba’s discovery efforts are focused on the regulation of dysfunctional permeability through a variety of mechanisms, including through the use of permeability inhibitors, depicted in the videos above.
By inhibition of inappropriate permeability through a variety of mechanisms, Alba strives to modify disease progression while downregulating the associated inflammatory cascade.